| 2024 | |
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Winter S, Götze KS, Hecker JS, Metzeler KH, Guezguez B, Woods K, Medyouf H, Schäffer A, Schmitz M, Wehner R, Glauche I, Roeder I, Rauner M, Hofbauer LC, Platzbecker U
Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche. Leukemia (2024), DOI Link |
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| 2023 | |
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Hoffmann K, Pelz A, Karg E, Gottschalk A, Zerjatke T, Schuster S, Böhme H, Glauche I, Roeder I
Data integration between clinical research and patient care: A framework for context-depending data sharing and in silico predictions. PLOS digital health 2 (2023) e0000140, DOI Link |
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Martens N, Herzog M, Herold J, Bendig J, Günther L, Vogt M, Brombach M, Sieghardt S, Roeder I, Hampe J
Clinicum Digitale: Interim Report of an Interprofessional Course to Shape Digital Health Pioneers 2023 IEEE 2nd German Education Conference (GECon) (2023), DOI Link |
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Stumpf J, Anders L, Siepmann T, Schwöbel J, Karger C, Lindner T, Faulhaber-Walter R, Langer T, Escher K, Anding-Rost K, Seidel H, Hüther J, Pistrosch F, Martin H, Schewe J, Stehr T, Meistring F, Paliege A, Schneider D, Bast I, Steglich A, Gembardt F, Kessel F, Kröger H, Arndt P, Sradnick J, Frank K, Skrzypczyk S, Anft M, Klimova A, Mauer R, Roeder I, Tonn T, Babel N, Hugo C
9-Month observational Dia-Vacc study of vaccine type influence on SARS-CoV-2 immunity in dialysis and kidney transplant patients. Vaccine (2023), DOI Link |
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| 2022 | |
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Karg E, Baldow C, Zerjatke T, Clark RE, Roeder I, Fassoni AC, Glauche I
Modelling of immune response in chronic myeloid leukemia patients suggests potential for treatment reduction prior to cessation. Frontiers in oncology 12 (2022) 1028871, DOI Link |
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Mikhaylenko N, Wahnschaffe L, Herling M, Roeder I, Seifert M
Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemia. PloS one 17 (2022) e0274463, DOI Link |
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Schwarz A, Roeder I, Seifert M
Comparative Gene Expression Analysis Reveals Similarities and Differences of Chronic Myeloid Leukemia Phases. Cancers 14 (2022), DOI Link |
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Salmon M, White HE, Zizkova H, Gottschalk A, Motlova E, Cerveira N, Colomer D, Coriu D, Franke GN, Gottardi E, Izzo B, Jurcek T, Lion T, Schäfer V, Venturi C, Vigneri P, Zawada M, Zuna J, Hovorkova L, Koblihova J, Klamova H, Markova MS, Srbova D, Benesova A, Polivkova V, Zackova D, Mayer J, Roeder I, Glauche I, Ernst T, Hochhaus A, Polakova KM, Cross NCP
Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy. Leukemia 36 (2022) 1879-1886, DOI Link |
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Sidorova OA, Sayed S, Paszkowski-Rogacz M, Seifert M, Camgöz A, Roeder I, Bornhäuser M, Thiede C, Buchholz F
RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Cells 11 (2022), DOI Link |
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Sobe H, Richter M, Berner R, von der Hagen M, Hähner A, Röder I, Koch T, Sabatowski R, Klimova A, Gossrau G
Functional improvement in children and adolescents with primary headache after an interdisciplinary multimodal therapy program: the DreKiP study. The journal of headache and pain 23 (2022) 109, DOI Link |
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| 2021 | |
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Hoffmann H, Baldow C, Zerjatke T, Gottschalk A, Wagner S, Karg E, Niehaus S, Roeder I, Glauche I, Scherf N
How to predict relapse in leukemia using time series data: A comparative in silico study. PloS one 16 (2021) e0256585, DOI Link |
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Roeder I, Glauche I
Overlooking the obvious? On the potential of treatment alterations to predict patient-specific therapy response. Experimental hematology 94 (2021) 26-30, DOI Link |
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Wagner S, Thierbach K, Zerjatke T, Glauche I, Roeder I, Scherf N
TraCurate: Efficiently curating cell tracks SoftwareX 13 (2021) 100656, DOI Link |
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Waschke J, Hlawitschka M, Anlas K, Trivedi V, Roeder I, Huisken J, Scherf N
linus: Conveniently explore, share, and present large-scale biological trajectory data in a web browser. PLoS computational biology 17 (2021) e1009503, DOI Link |
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| 2020 | |
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Diebner HH, Kather A, Roeder I, de With K
Mathematical basis for the assessment of antibiotic resistance and administrative counter-strategies. PloS one 15 (2020) e0238692, DOI Link |
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Gottschalk A, Glauche I, Cicconi S, Clark RE, Roeder I
Molecular monitoring during dose reduction predicts recurrence after TKI cessation in CML. Blood 135 (2020) 766-769, DOI Link |
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Hoffmann H, Thiede C, Glauche I, Bornhaeuser M, Roeder I
Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: insights from a mathematical modelling approach. Journal of the Royal Society, Interface 17 (2020) 20200091, DOI Link |
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Hoffmann K, Cazemier K, Baldow C, Schuster S, Kheifetz Y, Schirm S, Horn M, Ernst T, Volgmann C, Thiede C, Hochhaus A, Bornhäuser M, Suttorp M, Scholz M, Glauche I, Loeffler M, Roeder I
Integration of mathematical model predictions into routine workflows to support clinical decision making in haematology. BMC medical informatics and decision making 20 (2020) 28, DOI Link |
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Hähnel T, Baldow C, Guilhot J, Guilhot F, Saussele S, Mustjoki S, Jilg S, Jost PJ, Dulucq S, Mahon FX, Roeder I, Fassoni AC, Glauche I
Model-based inference and classification of immunological control mechanisms from TKI cessation and dose reduction in CML patients. Cancer research 80 (2020) 2394-2406, DOI Link |
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Lauber C, Correia N, Trumpp A, Rieger MA, Dolnik A, Bullinger L, Roeder I, Seifert M
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients. Scientific reports 10 (2020) 12761, DOI Link |
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Bondarieva A, Raveendran K, Telychko V, Rao HBDP, Ravindranathan R, Zorzompokou C, Finsterbusch F, Dereli I, Papanikos F, Tränkner D, Schleiffer A, Fei JF, Klimova A, Ito M, Kulkarni DS, Roeder I, Hunter N, Tóth A
Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nature communications 11 (2020) 3101, DOI Link |
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Erdmann K, Salomo K, Klimova A, Heberling U, Lohse-Fischer A, Fuehrer R, Thomas C, Roeder I, Froehner M, Wirth MP, Fuessel S
Urinary MicroRNAs as Potential Markers for Non-Invasive Diagnosis of Bladder Cancer. International journal of molecular sciences 21 (2020), DOI Link |
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Johansson P, Klein-Hitpass L, Budeus B, Kuhn M, Lauber C, Seifert M, Roeder I, Pförtner R, Stuschke M, Dührsen U, Eckstein A, Dürig J, Küppers R
Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing. Cancers 12 (2020), DOI Link |
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Kloenne M, Niehaus S, Lampe L, Merola A, Reinelt J, Roeder I, Scherf N
Domain-specific cues improve robustness of deep learning-based segmentation of CT volumes. Scientific reports 10 (2020) 10712, DOI Link |
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Machova Polakova K, Zizkova H, Zuna J, Motlova E, Hovorkova L, Gottschalk A, Glauche I, Koblihova J, Pecherkova P, Klamova H, Stastna Markova M, Srbova D, Benesova A, Polivkova V, Jurcek T, Zackova D, Mayer J, Ernst T, Mahon FX, Saussele S, Roeder I, Cross NCP, Hochhaus A
Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission. Leukemia 34 (2020) 2113-2124, DOI Link |
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Oberbeck S, Schrader A, Warner K, Jungherz D, Crispatzu G, von Jan J, Chmielewski M, Ianevski A, Diebner HH, Mayer P, Kondo Ados A, Wahnschaffe L, Braun T, Müller TA, Wagle P, Bouska A, Neumann T, Pützer S, Varghese L, Pflug N, Thelen M, Makalowski J, Riet N, Göx HJM, Rappl G, Altmüller J, Kotrova M, Persigehl T, Hopfinger G, Hansmann ML, Schlößer H, Stilgenbauer S, Dürig J, Mougiakakos D, von Bergwelt-Baildon M, Roeder I, Hartmann S, Hallek M, Moriggl RH, Brüggemann M, Aittokallio T, Iqbal J, Newrzela S, Abken H, Herling M
Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling Blood (2020), DOI Link |
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| 2019 | |
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Hoffmann H, Thiede C, Glauche I, Kramer M, Röllig C, Ehninger G, Bornhäuser M, Roeder I
The prognostic potential of monitoring disease dynamics in NPM1-positive acute myeloid leukemia Leukemia 33 (2019) 1531-1534, DOI Link |
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Seurig S, de Back W, Scherf N, Röder I
Automating pollen counting using deep learning Allergo Journal Sep 2019 (2019) |
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de Back W, Zerjatke T, Roeder I
Statistical and Mathematical Modeling of Spatiotemporal Dynamics of Stem Cells Methods in Molecular Biology 2017 (2019) 219-243, DOI Link |
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Fassoni AC, Roeder I, Glauche I
To Cure or Not to Cure: Consequences of Immunological Interactions in CML Treatment Bulletin of Mathematical Biology (2019) 1-51, DOI Link |
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Nieswald V, Richter M, Berner R, von der Hagen M, Klimova A, Roeder I, Koch T, Sabatowski R, Gossrau G
The prevalence of headache in German pupils of different ages and school types Cephalalgia 39 (2019), DOI Link |
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Shah G, Thierbach K, Schmid B, Waschke J, Reade A, Hlawitschka M, Roeder I, Scherf N, Huiken J
Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish Nature Communications 10 (2019), DOI Link |
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Zakrzewski F, de Back W, Weigert M, Wenke T, Zeugner S, Mantey R, Sperling C, Friedrich K, Roeder I, Aust D, Baretton G, Hönscheid P
Automated detection of the HER2 gene amplification status in Fluorescence in situ hybridization images for the diagnostics of cancer tissues Scientific Reports 9 (2019), DOI Link |
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| 2018 | |
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Diebner HH, Zerjatke T, Griehl M, Roeder I
Metabolism is the tie: The Bertalanffy-type cancer growth model as common denominator of various modelling approaches Biosystems 167 (2018) 1-23, DOI Link |
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Gaspari E, Franke A, Robles-Diaz D, Zweigerdt R, Roeder I, Zerjatke T, Kempf H
Paracrine mechanisms in early differentiation of human pluripotent stem cells: Insights from a mathematical model Stem Cell Research 32 (2018) 1-7, DOI Link |
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Glauche I, Kuhn M, Baldow C, Schulze P, Rothe T, Liebscher H, Roy A, Wang X, Roeder I
Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison. Scientific Reports 8 (2018) 12330, DOI Link |
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Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PLM, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O
Whither systems medicine? Experimental & Molecular Medicine 50 (2018) e453, DOI Link |
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Fassoni AC, Baldow C, Roeder I, Glauche I
Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: A simulation study based on phase 3 trial data Haematologica 103 (2018) 1825-1834, DOI Link |
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| 2017 | |
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Baldow C, Salentin S, Schroeder M, Roeder I, Glauche I
MAGPIE: Simplifying access and execution of computational models in the life sciences PLOS Computational Biology 13 (2017) 1-11, DOI Link |
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Proschmann R, Baldow C, Rothe T, Suttorp M, Thiede C, Tauer JT, Müller MC, Hochhaus A, Roeder I, Glauche I
Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy. Haematologica 102 (2017) e39-e42, DOI Link |
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Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K
Limitations and challenges of genetic barcode quantification Scientific Reports 7 (2017), DOI Link |
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Bandoła J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Dorschner B, Alexopoulou D, Navratiel K, Roeder I, Dahl A, Hedrich CM, Bonifacio E, Brenner S, Thieme S
Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells Front Immunol. 8 (2017) 1-16, DOI Link |
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Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I
Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion Mol Cancer 16:120 (2017) 1-12, DOI Link |
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Herling M, Rengstl B, Scholtysik R, Hartmann S, Küppers R, Hansmann ML, Diebner HH, Roeder I, Abken H, Newrzela S, Kirberg J
Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology Leukemia & Lymphoma 58 (2017) 788-796, DOI Link |
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Herold S, Kuhn M, von Bonin M, Stange T, Platzbecker U, Radke J, Lange T, Sockel K, Gutsche K, Schetelig J, Röllig C, Schuster C, Roeder I, Dahl A, Mohr B, Serve H, Brandts C, Ehninger G, Bornhäuser M, Thiede C
Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipient Leukemia (2017), DOI Link |
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Hohenstein B, Julius U, Lansberg P, Jaeger B, Mellwig KP, Weiss N, Graehlert X, Roeder I, Ramlow W
Rationale and design of MultiSELECt: A European Multicenter Study on the Effect of Lipoprotein(a) Elimination by lipoprotein apheresis on Cardiovascular outcomes Atherosclerosis Supplements (2017) 180-186, DOI Link |
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MacLean AL, Smith MA, Liepe J, Sim A, Khorshed R, Rashidi NM, Scherf N, Krinner A, Roeder I, Lo Celso C, Stumpf MPH
Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection Stem Cells 35 (2017) 2292–2304, DOI Link |
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| 2016 | |
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Diebner HH, Marrè B, Roeder I, Walter MH
Process-based approach to modeling recurrent-event data explicated on the basis of occurrences of tooth losses in two different prosthetic treatment concepts Trials 17 (2016) 244, DOI Link |
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Glauche I, Scholz M, Löffler M, Roeder I
durch simulation zur optimierten therapie - e:Med-Demonstrator-Projekt HaematoOPT erarbeitet Strategien fuer modellbasierte Optimierung haematologischer Therapien systembiologie.de 11 (2016) 78-82 |
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Herberg M, Glauche I, Zerjatke T, Winzi M, Buchholz F, Roeder I
Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics. Journal of the Royal Society, Interface 13 (2016) 1-10, DOI Link |
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Kuhn M, Stange T, Herold S, Thiede C, Roeder I
Finding small somatic structural variants in exome sequencing data: a machine learning approach Computational Statistics (2016) 1-14, DOI Link |
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Roeder I, Scholz M, Glauche I
Systemmedizinische Ansätze in Hämatologie und Onkologie Spectrum Onkologie 06 (2016) 50-52 |
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Thierbach K, Shah G, Glauche I, Huisken J, Roeder I, Scherf N
Biology-inspired visualization of morphogenetic motion in the zebrafish endoderm In: IEEE: Conference Proceedings : 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI) (2016), ISBN: 978-1-4799-2349-6 |
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Schoedel KB, Morcos MN, Zerjatke T, Roeder I, Grinenko T, Voehringer D, Göthert JR, Waskow C, Roers A, Gerbaulet A
The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood (2016) 1-13, DOI Link |
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| 2015 | |
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Diebner HH, Kirberg J, Roeder I
An evolutionary stability perspective on oncogenesis control in mature T-cell populations. Journal of theoretical biology (2015), DOI Link |
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Herberg M, Roeder I
Computational modelling of embryonic stem-cell fate control. Development (Cambridge, England) 142 (2015) 2250-60, DOI Link |
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Herberg M, Zerjatke T, de Back W, Glauche I, Roeder I
Image-based quantification and mathematical modeling of spatial heterogeneity in ESC colonies. Cytometry. Part A : the journal of the International Society for Analytical Cytology (2015), DOI Link |
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Chmelova H, Cohrs CM, Chouinard JA, Petzold C, Kuhn M, Chen C, Roeder I, Kretschmer K, Speier S
Distinct roles of beta cell mass and function during type 1 diabetes onset and remission. Diabetes (2015), DOI Link |
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Garthe A, Roeder I, Kempermann G
Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis. Hippocampus (2015), DOI Link |
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Giordano FA, Appelt JU, Link B, Gerdes S, Lehrer C, Scholz S, Paruzynski A, Roeder I, Wenz F, Glimm H, von Kalle C, Grez M, Schmidt M, Laufs S
High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies. Molecular therapy. Methods&clinical development 2 (2015) 14061, DOI Link |
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Niederberger T, Failmezger H, Uskat D, Poron D, Glauche I, Scherf N, Roeder I, Schroeder T, Tresch A
Factor graph analysis of live cell imaging data reveals mechanisms of cell fate decisions. Bioinformatics (Oxford, England) (2015), DOI Link |
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| 2014 | |
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Glauche I, Baldow Ch, Fröhlich S, Schulze P, Roy A, Subar M, Wang X, Roeder I
Model-Based Characterization of the Molecular Response Dynamics of Tyrosine Kinase Inhibitor (TKI)-Treated CML Patients a Comparison of Imatinib and Dasatinib First-Line Therapy Blood 124 (2014) 4562 |
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Glauche I, Roeder I
in silico hematology Systembiologie.de 42 (2014) 19 |
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Herberg M, Kalkan T, Glauche I, Smith A, Roeder I
A Model-Based Analysis of Culture-Dependent Phenotypes of mESCs. PloS one 9 (2014) e92496, DOI Link |
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Krinner A, Roeder I
Quantification and modeling of stem cell-niche interaction. Advances in experimental medicine and biology 844 (2014) 11-36, DOI Link |
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Krinner A, Roeder I
Quantification and Modeling of Stem Cell-Niche Interaction In: Seth J Corey, Marek Kimmel and Joshua N. Leonard (Eds.): A Systems Biology - Approach to Blood Springer Science+Business Media (2014), ISBN: 978-1-4939-2094-5 |
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Bach E, Zerjatke T, Herklotz M, Scherf N, Niederwieser D, Roeder I, Pompe T, Cross M, Glauche I
Elucidating functional heterogeneity in hematopoietic progenitor cells: a combined experimental and modeling approach. Experimental hematology 42 (2014) 826-37.e1-17, DOI Link |
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Beyer-Westendorf J, Gelbricht V, Förster K, Ebertz F, Röllig D, Schreier T, Tittl L, Thieme C, Hänsel U, Köhler C, Werth S, Kuhlisch E, Stange T, Röder I, Weiss N
Safety of switching from vitamin K antagonists to dabigatran or rivaroxaban in daily care--results from the Dresden NOAC registry. British journal of clinical pharmacology 78 (2014) 908-17, DOI Link |
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Cornils K, Thielecke L, Hüser S, Forgber M, Thomaschewski M, Kleist N, Hussein K, Riecken K, Volz T, Gerdes S, Glauche I, Dahl A, Dandri M, Roeder I, Fehse B
Multiplexing clonality: combining RGB marking and genetic barcoding. Nucleic acids research (2014), DOI Link |
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Knaack S, Lode A, Hoyer B, Rösen-Wolff A, Gabrielyan A, Roeder I, Gelinsky M
Heparin modification of a biomimetic bone matrix for controlled release of VEGF. Journal of biomedical materials research. Part A 102 (2014) 3500-11, DOI Link |
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Lützner C, Voigt H, Roeder I, Kirschner S
Placement makes a difference: Accuracy of an accelerometer in measuring step number and stair climbing. Gait&posture (2014), DOI Link |
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Rashidi NM, Scott MK, Scherf N, Krinner A, Kalchschmidt JS, Gounaris K, Selkirk ME, Roeder I, Lo Celso C
In vivo time-lapse imaging of mouse bone marrow reveals differential niche engagement by quiescent and naturally activated hematopoietic stem cells. Blood (2014), DOI Link |
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| 2013 | |
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Gerdes S, Newrzela S, Glauche I, von Laer D, Hansmann ML, Roeder I
Mathematical modeling of oncogenesis control in mature T-cell populations. Frontiers in immunology 4 (2013) 380, DOI Link |
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Glauche I, Bystrykh L, Eaves C, Roeder I
Stem cell clonality - Theoretical concepts, experimental techniques, and clinical challenges. Blood cells, molecules&diseases (2013), DOI Link |
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Krinner A, Roeder I, Loeffler M, Scholz M
Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis. BMC systems biology 7 (2013) 117, DOI Link |
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Scherf N, Ludborzs C, Thierbach K, Glauche I, Roeder I
A Fluid Registration Approach to Cell Tracking Current Medical Imaging Reviews 9 (2013) 102-12 |
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Scherf N, Zerjatke T, Klemm K, Glauche I, Roeder I
Beyond Genealogies: Mutual information of causal paths to analyse single cell tracking data In: IEEE: 10th International Symposium on Biomedical Imaging: From Nano to Macro, San Francisco, CA, USA, April 7-11, 2013 (2013), ISBN: 978-1-4673-6454-6/13 |
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Scherf N, Kunze M, Thierbach K, Zerjatke T, Burek P, Herre H, Glauche I, Roeder I
Assisting the Machine Paradigms for Human-Machine Interaction in Single Cell Tracking In: Hans-Peter Meinzer, Thomas Martin Deserno, Heinz Handels, Thomas Tolxdorff (eds.): Bildverarbeitung für die Medizin 2013 Springer (2013), ISBN: 978-3-642-36479-2 (Print) 978-3-642-36480-8 (Online) |
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Cornils K, Bartholomae CC, Thielecke L, Lange C, Arens A, Glauche I, Mock U, Riecken K, Gerdes S, von Kalle C, Schmidt M, Roeder I, Fehse B
Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or gamma-retroviral LTR vector. Experimental hematology 41 (2013) 28-38.e3, DOI Link |
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Horn M, Glauche I, Müller MC, Hehlmann R, Hochhaus A, Loeffler M, Roeder I
Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Blood 121 (2013) 378-84, DOI Link |
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Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, Yang M, Li Z, Schambach A, Heinz N, Gerdes S, Roeder I, Ha TC, Steinemann D, Schlegelberger B, Baum C
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells. Leukemia 27 (2013) 1127-38, DOI Link |
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Schmid B, Shah G, Scherf N, Weber M, Thierbach K, Campos CP, Roeder I, Aanstad P, Huisken J
High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics. Nature communications 4 (2013) 2207, DOI Link |
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| 2012 | |
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Glauche I, Horn K, Horn M, Thielecke L, Essers MA, Trumpp A, Roeder I
Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations. British journal of cancer 106 (2012) 1742-52, DOI Link |
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Scherf N, Herberg M, Thierbach K, Zerjatke T, Kalkan T, Humphreys P, Smith A, Glauche I, Roeder I
Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions. Bioinformatics (Oxford, England) 28 (2012) i556-i561, DOI Link |
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Scherf N, Ludborzs Ch, Kuska JP, Braumann UD, Scheibe P, Pompe T, Glauche I, Roeder I
FluidTracks - Combining Nonlinear Image Registration and Active Contours for Cell Tracking In: Tolxdorff, Th.; Deserno, Th.M.; Handels, H.; Meinzer, H.-P. (Hrsg.): Proc. Bildverarbeitung für die Medizin 2012 Springer (2012), ISBN: 978-3-643-28502-8 |
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Scherf N, Franke K, Glauche I, Kurth I, Bornhäuser M, Werner C, Pompe T, Roeder I
On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup. Experimental hematology 40 (2012) 119-130.e9, DOI Link |
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Newrzela S, Al-Ghaili N, Heinrich T, Petkova M, Hartmann S, Rengstl B, Kumar A, Jäck HM, Gerdes S, Roeder I, Hansmann ML, von Laer D
T-cell receptor diversity prevents T-cell lymphoma development. Leukemia 26 (2012) 2499-507, DOI Link |
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| 2011 | |
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Glauche I., Roeder I.
Heterogeneity and Flexibility of Stem Cell Fate Decisions â?? A Conceptual Perspective In: Michal K. Stachowiak & Emmanuel S. Tzanakakis (Eds.): Stem Cells: From Mechanisms to Technologies World Scientific Publishing Co (2011), ISBN: 978-9814317702 |
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Glauche I, Thielecke L, Roeder I
Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modeling perspective. Aging cell 10 (2011) 457-65, DOI Link |
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Herberg M, Roeder I
Epigenetic Nanog regulation and the role of functional heterogeneity. Cell cycle (Georgetown, Tex.) 10 (2011) 1488-98 |
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Roeder I, Loeffler M, Glauche I
Towards a quantitative understanding of stem cell-niche interaction: Experiments, models, and technologies. Blood cells, molecules & diseases 46 (2011) 308-17, DOI Link |
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Giordano FA, Sorg UR, Appelt JU, Lachmann N, Bleier S, Roeder I, Kleff V, Flasshove M, Zeller WJ, Allgayer H, Kalle C, Fruehauf S, Moritz T, Laufs S
Clonal Inventory Screens Uncover Monoclonality Following Serial Transplantation of MGMT(P140K)-Transduced Stem Cells and Dose-Intense Chemotherapy. Human gene therapy 22 (2011) 697-710, DOI Link |
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| 2010 | |
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Glauche I, Herberg M, Roeder I
Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. PLoS one 5 (2010) e11238, DOI Link |
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Burek P, Herre H, Roeder I, Glauche I, Scherf N, Loeffler M
Towards a Cellular Genealogy Ontology In: H. Herre, R. Hoehndorf, J. Kelso, S. Schulz (eds.): 2nd Workshop of the GI-Fachgruppe "Ontologien in Biomedizin und Lebenswissenschaften (OBML)", 09-10. September 2010 in Mannheim, Germany Universität Leipzig (2010), ISBN: ISSN 1610-7233 |
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| 2009 | |
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Appelt JU, Giordano FA, Ecker M, Roeder I, Grund N, Hotz-Wagenblatt A, Opelz G, Zeller WJ, Allgayer H, Fruehauf S, Laufs S
QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis. Gene therapy 16 (2009) 885-93, DOI Link |
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Glauche I, Lorenz R, Hasenclever D, Roeder I
A novel view on stem cell development: analysing the shape of cellular genealogies. Cell proliferation 42 (2009) 248-63, DOI Link |
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Glauche I, Moore K, Thielecke L, Horn K, Loeffler M, Roeder I
Stem cell proliferation and quiescence--two sides of the same coin. PLoS computational biology 5 (2009) e1000447, DOI Link |
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Köhler C, Manteufel J, Röder I, Rösler U, Truyen U
Vergleichende Untersuchungen zur Tenazität verschiedener Modellviren gegenüber chemischen Desinfektionsmitteln (Comparative investigations on tenacity of different model viruses for testing chemical disinfectants) Hygiene Medizin 34 (2009) 224-32 |
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Roeder I, Herberg M, Horn M
An"age"-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia. Bulletin of mathematical biology 71 (2009) 602-26, DOI Link |
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Roeder I, Radtke F
Stem cell biology meets systems biology. Development (Cambridge, England) 136 (2009) 3525-30, DOI Link |
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Roeder I, d′Inverno M
New experimental and theoretical investigations of hematopoietic stem cells and chronic myeloid leukemia. Blood cells, molecules & diseases 43 (2009) 88-97, DOI Link |
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Röder I
Model-Based Analysis of Stem Cell Dynamics - An Application of Medical Systems Biology Habilitation (2009) University of Leipzig |
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d'Inverno M, Howells P, Montagna S, Roeder I, Saunders R
Agent-Based Modeling of Stem Cells In: Adelinde M. Uhrmacher, Danny Weyns (eds.): Multi-Agent Systems Taylor & Francis Group (CRC Press) (2009), ISBN: 978-1-4200-7023-1 |
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| 2008 | |
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Fehse B, Roeder I
Insertional mutagenesis and clonal dominance: biological and statistical considerations. Gene therapy 15 (2008) 143-53, DOI Link |
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Horn M, Loeffler M, Roeder I
Mathematical modeling of genesis and treatment of chronic myeloid leukemia. Cells, tissues, organs 188 (2008) 236-47, DOI Link |
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Roeder I, Glauche I
Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia--insights from mathematical model analyses. Journal of molecular medicine (Berlin, Germany) 86 (2008) 17-27, DOI Link |
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Roeder I, Horn K, Sieburg HB, Cho R, Muller-Sieburg C, Loeffler M
Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach. Blood 112 (2008) 4874-83, DOI Link |
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Scherf N, Roeder I, Glauche I
Correlation patterns of cellular genealogies In: Miika Ahdesmäki, Korbinian Strimmer, Nicole Radde, Jörg Rahnenführer, Konstantin Klemm, Harri Lähdesmäki, Olli Yli-Harja (eds.): Proccedings of the Fifth International Workshop on Computational Systems Biology (WCSB), June 11-13 2008, Leipzig, Germany Tampere International Center for Signal Processing (2008), ISBN: 978-952-15-1988-8 |
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| 2007 | |
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Bozorgmehr F, Laufs S, Sellers SE, Roeder I, Zeller WJ, Zeller WJ, Dunbar CE, Fruehauf S
No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells. Stem cells (Dayton, Ohio) 25 (2007) 2610-8, DOI Link |
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Glauche I, Cross M, Loeffler M, Roeder I
Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications. Stem cells (Dayton, Ohio) 25 (2007) 1791-9, DOI Link |
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Glauche I, Horn M, Roeder I
Leukaemia stem cells: hit or miss? British Journal of Cancer 96 (2007) 677-9, DOI Link |
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Roeder I, Braesel K, Lorenz R, Loeffler M
Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization. Journal of biomedicine&biotechnology 2007 (2007) 84656, DOI Link |
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| 2006 | |
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Kirkland MA, Quesenberry PJ, Roeder I
Discrete stem cells: subsets or a continuum? Blood 108 (2006) 3949; author reply 3950, DOI Link |
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Roeder I
Quantitative stem cell biology: computational studies in the hematopoietic system. Current opinion in hematology 13 (2006) 222-8, DOI Link |
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Roeder I
Systems stem cell biology In: Rubem P. Mondaini, Rui Dilão (eds.): BIOMAT 2006 - International Symposium on Mathematical and Computational Biology (Manaus, Brazil, 27 â?? 30 November 2006) World Scientific Publishing Co. (2006), ISBN: 978-981-270-768-0 |
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Roeder I, Galle J, Loeffler M
Theoretical Concepts of Tissue Stem-Cell Organization In: Christopher S. Potten, Robert B. Clarke, James Wilson, Andrew Renehan: Tissue stem cells Taylor & Francis Group (CRC Press) (2006), ISBN: 0-8247-2899-8 |
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Roeder I, Glauche I
Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1. Journal of theoretical biology 241 (2006) 852-65, DOI Link |
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Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M
Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nature medicine 12 (2006) 1181-4, DOI Link |
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Roeder I, Lorenz R
Asymmetry of stem cell fate and the potential impact of the niche: observations, simulations, and interpretations. Stem cell reviews 2 (2006) 171-80, DOI Link |
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| 2005 | |
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Krohn K, Eszlinger M, Paschke R, Roeder I, Schuster E
Increased power of microarray analysis by use of an algorithm based on a multivariate procedure. Bioinformatics (Oxford, England) 21 (2005) 3530-4, DOI Link |
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Roeder I, Kamminga LM, Braesel K, Dontje B, de Haan G, Loeffler M
Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization. Blood 105 (2005) 609-16, DOI Link |
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Rupf S, Brader I, Vonderlind D, Kannengiesser S, Eschrich K, Roeder I, Merte K
In vitro, clinical, and microbiological evaluation of a linear oscillating device for scaling and root planing. Journal of periodontology 76 (2005) 1942-9, DOI Link |
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| 2004 | |
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Loeffler M, Roeder I
Conceptual models to understand tissue stem cell organization. Current opinion in hematology 11 (2004) 81-7, DOI Link |
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Roeder I, Loeffler M
Simulation of Haematopoietic Stem Cell Organisation Using a Single Cell Based Model Approach In: Andreas Deutsch, Jonathon Howard, Martin Falcke, Walter Zimmermann (eds.): Function and Regulation of Cellular systems Birkhäuser Verlag (2004), ISBN: 3-7643-6925-6 |
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Schuster E, Kropf S, Roeder I
Micro array based gene expression analysis using parametric multivariate tests per gene a generalized application of multiple procedures with data-driven order of hypotheses Biometrical Journal 46 (2004) 687-98, DOI Link |
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| 2003 | |
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Roeder I, Loeffler M, Quesenberry PJ, Colvin GA, Lambert JF
Quantitative tissue stem cell modeling. Blood 102 (2003) 1143-4; author reply 1144-5, DOI Link |
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Röder I
Dynamical Modeling of Hematopoietic Stem Cell Organization - Design and Validation of the New Concept of Within-Tissue Plasticity PhD thesis (2003) University of Leipzig |
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| 2002 | |
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Loeffler M, Roeder I
Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models--a conceptual approach. Cells, tissues, organs 171 (2002) 8-26, DOI Link |
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Roeder I, Loeffler M
A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity. Experimental hematology 30 (2002) 853-61, DOI Link |
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| 2000 | |
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Dette H, Roeder I
Online calculation of efficient designs for multi-factor models Biometrical Journal 42 (2000) 349-62 |
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Leinung S, Würl P, Schönfelder A, Weiss CL, Röder I, Schönfelder M
Detection of cytokeratin-positive cells in bone marrow in breast cancer and colorectal carcinoma in comparison with other factors of prognosis Journal of Hematotherapy & Stem Cell Research 9 (2000) 905-11 |
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Leinung S, Würl P, Schönfelder A, Weiss CL, Röder I, Schönfelder M
Detection of cytokeratin-positive cells in bone marrow in breast cancer and colorectal carcinoma in comparison with other factors of prognosis Journal of Hematotherapy & Stem Cell Research 9 (2000) 905-11 |
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Leinung S, Würl P, Schönfelder A, Weiss CL, Röder I, Schönfelder M
Rating of isolated disseminated tumor cells in bone marrow in comparison with other factors of prognosis in breast carcinoma. Int J Surg Investig 2 (2000) 193-202 |
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Leinung S, Würl P, Weiss CL, Röder I, Schönfelder M
Cytokeratin-positive cells in bone marrow in comparison with other prognostic factors in colon carcinoma Langenbecks Archives of Surgery 385 (2000) 337-43 |
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| 1998 | |
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Roeder I, de Haan G, Engel C, Nijhof W, Dontje B, Loeffler M
Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 91 (1998) 3222-9, DOI Link |
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| 1997 | |
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Dette H, Röder I
Optimal discrimination designs for multifactor experiments Annals of Statistics 25 (1997) 1161-75 |
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| 1996 | |
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Dette H, Röder I
Optimal product designs for multivariate regression with missing terms Scandinavian Journal of Statistics 23 (1996) 195-208 |
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